If you’re an expectant mom, chances are you may have the opportunity to provide a truly valuable service to your family or to somebody else with real medical needs. The service is based on the practice of stem cell preservation. Stem cell preservation is a painless and effortless way to provide life giving cells to someone in need.

You see, at the time of birth, the umbilical cord connecting the mother and baby holds an incredible resource, cord blood carrying stem cells. These stem cells are extremely adaptable, and can be utilized in rebuilding an immune system or a blood system. As the baby is delivered and begins to take its own first breaths, that umbilical cord is severed and the practice of stem cell preservation can begin. Blood is drawn from the umbilical cord, and a short while later is treated under laboratory conditions to a state of deep freezing.

In considering the value of stem cell preservation, imagine the challenges of facing life-threatening diseases. Life suddenly becomes fragile for friends, family, loved ones.  A life threatening disease might sound a little like floating alone in the middle of a deep ocean. However, your life giving experience of becoming a mother can also be a life giving event for someone you may never meet.

Stem Cell Preservation – a Life Preserver

Now think of the relief, the joy, and the exhilaration of being tossed a medical life preserver.  As of 2006, over 8,000 people had received that life-preserver in the way of precious stem cells deriving from cord blood. Stem cell preservation (from cord blood and bone marrow) is proving to be a significant medical healing practice and is helping open doors for treating the likes of leukemia, lymphoma, breast cancer, and Hodgkin’s disease, to name just a few.

How do you think the recipient of a stem cell transplant feels about stem cell preservation? One simple word could characterize this feeling: thankful.

Expectant mothers have the unique privilege of donating umbilical cord blood and contributing to stem cell preservation. The process of stem cell preservation is simple, non-invasive, and free of charge. Please consult with your doctor or midwife before the 34th week of pregnancy. Your decision to look into stem cell preservation could be represent a life preserver to someone who could really use the help.

Expectant mothers in the final few months of pregnancy, probably have heard, or even learned something about, stem cell preservation. Such preservation begins with the gathering of blood from the umbilical cord after your baby’s birth. Within thirty seconds of the baby’s arrival, one of the doctors or medical staff will cut the umbilical cord and draw about 1/3 of a cup of blood from the cord, and then secure it for transport to a nearby cord blood bank. This is the beginning of the process known as stem cell preservation.

The preservation aspect of stem cell preservation is actually quite uncomplicated. It involves storage of the blood and cells in subzero temperatures known as cryogenic freezing. Of course, there is more to stem cell preservation. The samples go through a detailed labeling and identification process, as well as tests for any transmittable diseases. It’s interesting to note that the cryogenic process is so effective that even the oldest cells available (stem cell preservation from cord blood started in 1990) show limited deterioration as they are used today.

You might be wondering what happens when the cells are thawed and issued and just who qualifies to benefit from cord blood stem cell transplants.

Stem Cell Preservation and Tissue Compatibility

Donors are matched to recipients according to six proteins, called Human Leukocyte Antigens (HLA), that appear on the surface of white blood cells and other tissues in the body. These six HLA points determine tissue compatibility which leads us to one of the real benefits of cord blood stem cell preservation. As a minimum, only three of the six HLA points need to be a match for a successful transplant. This makes it easier, and less risky, in finding patients with compatible tissues.

The most likely recipients of treatment from stem cell preservation will be those coming out of chemotherapy or radiation therapy; where the healing process starts by eliminating all the cells in the body. Stem cell preservation maintains cells that are highly adaptable and can be used with patients suffering from a number of diseases among them leukemia, different forms of cancer, and Hodgkin’s disease.

From Stem Cell Preservation to Treatment

The new cells supplied by stem cell preservation enter the body through a tube or central line that goes into a vein in the patient’s chest. The transplanted cells move into the spaces inside the bones where they create new marrow. They grow and make healthy new red blood cells, white blood cells and platelets. Isn’t that miraculous? The human body certainly is a healing marvel, and modern medicine continues to make vital strides in treating even the most challenging diseases.

At the center of this remarkable healing process is stem cell preservation.

Stem cell preservation is a medical breakthrough with immense possibilities for mankind. Expectant mothers, in particular, maybe very interested in collecting cord blood, because this blood may be used in the future to cure life-threatening conditions not only for the baby, but also potentially for its siblings and possibly unrelated recipients. There is absolutely no risk involved for the mother and child during cord blood collection for the stem cell preservation process.

In addition to cord blood stem cells being used to treat over 40 different diseases and disorders ranging from blood cancers to immune disorders, stem cells in general are currently being studied, with great success, in treating a myriad of diseases and disorders such as Alzheimer’s, Parkinson’s, stroke, heart disease, Type 1 diabetes, Cerebral Palsy, spinal cord injuries and organ regeneration.

Current estimates indicate that approximately 1 in 3 Americans could benefit from regenerative medicine, and children whose cord blood stem cells are available for their own potential use could be among the first to benefit from new therapies as they become available. With autologous (the person’s own) cells, there is no risk of an immune system rejecting the cells, so physicians and researchers are only performing these potential cord blood therapies on children who have their own stem cells available.1

As a result, it can be inferred that stem cell preservation is a form of insurance and security for your future life, which may potentially be used in the future.

1Harris DT, et al. (2007). “The potential of cord blood stem cells for use in regenerative medicine.”. Expert Opin. Biol. Ther. 7 (9): 1311–1322. doi:10.1517/14712598.7.9.1311. PMID 17727322.

In the past decade, most new parents have been given a choice of banking their baby’s cord blood or donating it to a public storage bank.  This is a once in a lifetime opportunity that is available when your baby is born and before the umbilical cord is discarded.  Collecting cord blood from the umbilical cord is a five minute procedure and will not hurt the mother or more importantly, the baby.   Umbilical cord blood stem cells are now being used to treat many malignant and non-malignant diseases and new uses for stem cells are being discovered everyday!

A lot of people ask why they should preserve cord blood and the answer is simple.  As most women are aware, during pregnancy the umbilical cord is the lifeline between mothers and their unborn babies.  Most of the time, after the delivery the umbilical cord is cut and then discarded.  The stem cells that are in the cord blood are also discarded.   These stem cells are an exact genetic match for the child.  If you were to preserve them, you would be guaranteeing your child a source of perfectly matched stem cells in the event that they were to develop a life threatening disease that could be treated using these cells.

Stem cells are used to treat a variety of diseases such as leukemia, Hodgkin’s disease, along with other cancers, blood diseases and some immune system disorders.  Researchers are striving to make stem cell transplants of use in fighting AIDS, Lupus, lung cancer and Multiple Sclerosis. The reason why they are so valuable is that stem cells have been known as the building blocks of blood and the immune system and also other tissues in our bodies.   They can also transform into other cell types such as red blood cells and white blood cells and platelets.  This is what makes them so valuable.   They can replace other cells in our body that are abnormal, weakened or ruined by disease. In fact one of the main uses of stem cells is to replace abnormal bone marrow cells.

Mention the term stem cell preservation to a crowd and you could be met with any number of responses anywhere from the admittedly uninformed, to the up-to-the-minute reader of the latest headlines on the subject.  Mention the term cord blood to the same group and most folks would respond by saying, “What”? How ironic that one of the easiest ways to contribute to the health and well-being of society is still largely unknown. How wonderful that the life giving gift of stem cell preservation is one that begins with the miracle of birth.

Stem Cell Preservation – Defined

Stem cell preservation is the gathering and saving of nutrient rich stem cells that are present in the body, especially the umbilical cord at birth. One immediate question you might have is why are stem cells so valuable? Importantly, stem cells are highly adaptable and can readily replicate into red blood cells, white blood cells, and platelets. Red blood cells are important because they carry oxygen to all the cells in the body; white blood cells are responsible for fighting infection; and platelets aid in clotting when the body is injured. These components are the basic elements of healthy blood and a strong immune system.

Stem Cell Preservation – Going to the Source

After knowing what “stem cell preservation” is and why it is valuable, we ask the next question – where do we find stem cells? Modern medicine names three primary sources: the fertilized embryo, within bone marrow, and within the blood of an umbilical cord. In the first instance, there’s a great deal of controversy from an ethical standpoint.  In the second there is a reasonably high level of risk, and in the third there are no ethical concerns and no real risk to mother or newborn.

For years, bone marrow transplants have been a common practice yielding somewhat inconsistent results in the treatment for certain kinds of cancers and leukemia. The number one challenge of this treatment, though, is the need for donor and recipient to be an exact marrow match. On the other hand, with cord blood treatments, the need for an exact match does not exist as the stem cells drawn from cord blood are more adaptable. This unique usefulness places a high level of importance on effective stem cell preservation.

Cord Blood – The Simplest Source

Stem cell preservation as it relates to umbilical cord blood is fairly simple, albeit somewhat futuristic sounding. Shortly after the birth of your newborn, his or her umbilical cord is clamped and cut; blood is drawn and transported to a lab where it is cryogenically frozen at temperatures in the neighborhood of -190 degrees. There is no risk to mom and baby and the transfer to a state of preservation is safe and exact.

Currently, stem cells are for the most part utilized in transplant medicine to regenerate a patient’s blood and immune system after they have been treated with chemotherapy and/or radiation to destroy cancer cells. Other more dynamic treatments are envisioned for the future as cord blood holds a very important place in stem cell preservation. Mother’s and their newborns are contributing to one of the most promising advances in medical technology everyday with the simple and safe methods of stem cell preservation.

With all the excitement over a new pregnancy, parents reading a pamphlet on cord blood storage may not be as high on their list as, say, decorating the nursery. However, cord blood storage, also know as stem cell preservation, marks one of the most exciting ways that the new life about to enter the world will impact those around it. New parents have a chance to use cord blood storage to save lives.

Since 1990, doctors have used the ability to gather and preserve some of the ultra-rich stem cells that thrive in the blood of a newborn’s umbilical cord. The process known as cord blood storage is quite simply getting umbilical blood to a lab after drawing it from the severed umbilical cord at birth and putting it in to a deep freeze. The cord blood storage, or cryogenic process is so effective that cells remain viable for more than 20 years and may show minimal deterioration.

The “good part” of the cord blood storage story

Stem cells are among the most dynamic and adaptable cells in the entire body, and they can be found in a baby’s umbilical cord blood. Once retrieved from cord blood storage (the state of being cryogenically frozen), the cells may be utilized in a number of ways.

Currently, stem cells are most commonly utilized in transplant medicine to regenerate a patient’s blood and immune system after the patient has been treated with chemotherapy and/or radiation to destroy cancer cells. The list of diseases where stem cells can assist with the healing process is lengthy, and supports the value of cord blood storage a many times over. The list includes leukemia, lymphoma, Hodgkin’s disease, Aplastic Anemia, Sickle Cell Anemia, various other cancers, blood diseases, hereditary/genetic conditions and immune system disorders. In addition, current research holds significant promise for improving the treatment of some of the most common diseases such as heart disease, stroke, and Alzheimer’s with the stem cells preserved during cord blood storage.

Research shows that the blood that comes from a baby’s umbical cord is a rich source of stem cells.   Stem cells have the ability to differentiate into other tissues and blood vessels and can be used to treat a variety of diseases.   Up until recently stem cells came from bone marrow, but because these were usually matured stem cells they had an increase chance of being rejected.   Stem cells that are found in the umbical cord are still immature and haven’t learned to attack any foreign substances which makes them less likely to be rejected.

Research is being done that shows cord blood, and the stem cells found in this blood, could be used in the future to treat people with diabetes, heart failure, stroke and even some neurological disorders.   Keep in mind that the use of stem cells is still being researched and tested thoroughly and according to researchers we are still in the early stages of understanding the full potential of stem cells.

Other benefits of stem cells is their ability to go through numerous cycles of cell division and the capacity to differentiate into specialized cell types. By doing this, using stem cells is the best option for replacing cells that have been damaged by diseases such as cancer.    They are also the basis for the embryo when it first develops and are present in the umbical cord and placenta.  This is why so many companies have been offering new parents not just the opportunity to donate their baby’s cord blood which is full of stem cells, but to store their baby’s cord blood privately for use of the child only or for an immediate family member.

Even though stem cell research has been a huge debate in the medical world, there is no denying all the potential benefits they offer.   There have been numerous amounts of stem cell transplants that were successful and gave people a second chance at life.

When my husband and I found out we were expecting our second child this Thanksgiving, the first thing we did was jump online and sign up on all the baby sites for free baby things.   Pretty soon our mail box was being filled with all sorts of coupons and advertisements, among them, companies offering to bank our baby’s cord blood.

Cord blood, for those who may not know, is the blood that remains in the umbical cord and the placenta following birth.   We all know that the placenta and umbical cord play an extremely important role during pregnancy.  It is the life line for our babies.  After delivery the blood in the umbical cord could save not only your baby’s life if need be, but others too.   The reason is because of the extensive amount of stem cells found in the blood that can be used in the fight against leukemia, lymphoma, and other life-threatening diseases.    Usually, these cells work best when they are used in the patients own body but you do not have to store cord blood just for your baby.  There are many options.

First, you can store the blood in a private family cord blood bank.  This is where the blood is collected and stored should your child or matching family member ever need it.  While it gives some parent’s peace of mind that there is some form of treatment available should something ever happen to their children, there is a cost.  First, some companies charge anywhere in the vicinity of $1700 just to collect the blood.  Second, the blood is stored long term using cyopreservation and there is usually a yearly fee for storage.   Some companies offer payment plans to help out.

You can also donate to a public bank.   Donating your baby’s cord blood is not going to cost you anything, and you could be saving someone’s life.   In order to do this, find out if your hospital collects the umbilical cord blood donations and work with them to find out if you are eligible to donate.  In order to be eligible to donate you must be at least 18 years of age, HIV negative and have no risk to HIV or AIDS.  You also must be cancer free and not a diabetic.  If you were diagnosed with gestational diabetes during your pregnancy you should still be able to donate, but if you had any tattoo or piercing with in the last 12 months you are not eligible.

Most cord blood banking companies state that your baby’s cord blood will be stored in a state of the art cryoprservation center.  This is the number one choice of most cord blood storage banks.  It is the method that protects and preserves your baby’s stem cells should they ever be needed.    Some of you might be wondering what cryopreservation really is.   It is the process where cells are preserved by cooling them to low sub-zero temperatures.  This temperature is typically 77K or -196 degrees C.   At these low temperatures there is no biological activity.   In fact, the biochemical reactions that cause cell death are stopped ensuring that the cells are still of good quality when the time comes for them to be used.

There are some risks though during cryoprservation.  The solution that is used during cryopreservation can sometimes cause damage to cells.  Solutions that have a high salt concentration can be very damaging to stem cells.   Other factors that can cause damage to cells are extracellular ice formation or ice forming on the outside of the cell.  When tissues are cooled, water will sometime seep out of the cells and ice form in its place.   Too much of this ice can cause mechanical damage due to crushing.   You also have to think about dehydration.   The migration of the water that seeps out of the cells and causes extracellular ice formation is also the cause of cellular dehydration.   The cells are losing water, and the stress that is caused on the cell is often damaging.     You have to consider ice forming on the inside of cells also.  While some tissues can tolerate some extracellular ice, intracellular ice is always fatal to cells.

So how can cord blood banks prevent this when storing your baby’s cord blood?  One way to prevent it is through vitrification.  This provides the benefits of cryopreservation without any damage due to ice crystals.  How vitrification works is with the addition of cryoprotectants.  These cryoprotentants act like antifreeze and lower the freezing temperature.  In artificial cryopreservation, the solute must penetrate the membrane of the cell in order to achieve increased viscosity and slow down the freezing temperature inside the cells.

Cryopreservation has also been used in preserving embryos for couples who have used IVF or invitro fertilization and it works the same way as it does for storing cord blood.   Knowing just how they will keep your baby’s blood will aid you in making the decision that is right for you.

Whether you have decided to store your baby’s cord blood at a private storage bank or whether you have decided to donate your newborn’s cord blood, there are some steps you need to take before your bundle of joy is due.   Researching private blood storage banks and finding out if your hospital participates in any donor programs should be added to an expectant parent’s to do list before the 30th week. 

Whether you are storing or donating, you must make sure to receive the cord blood collection kit from the chosen cord blood bank.  If you are storing your newborn’s blood privately, you will be charged for this service.  If you are donating your baby’s blood, some hospitals might already keep a cord blood collection kit on hand, so may not have to bring one with you to your delivery.

With a normal vaginal delivery, the cord blood is collected before the placenta is delivered.   The umbilical cord is clamped on both sides and then an experienced obstetrician or a nurse will unclamp one side of the umbilical cord and insert either a small tube or a small needle into the umbilical vein to collect the blood.  Other times, the blood is dripped into either a vial or a special collection bag.   After this is collected, a needle could also be placed into the placenta to collect more blood and cells.  These cells will be in their own containers and properly identified.

During a cesarean or C-section birth, the collection process is a little more complicated but still causes no pain to the mother or to the baby.   During C-sections, a doctor’s main focus is the mother and baby.  After all, this is a major surgery and there are a number of complications that can arise.   It is only after the baby has been safely delivered, along with the placenta and the mother’s uterus has been sutured that the cord blood can be collected.   Usually though less blood is collected when the baby is delivered via C-section.   That can sometimes be a problem, because less blood collected also means fewer stem cells collected and stored.   Some doctors feel that there is too big of a risk of contamination by collecting cord blood after a C-section, but for the most part most public and private cord storage banks have taken the proper steps to reduce the risk of contamination by providing sterile kit components.